Prime IV Hydration & Wellness is the nation’s fastest-growing IV therapy franchise, delivering proprietary vitamin, mineral, and amino acid infusions in a spa-like environment. Founded in 2017 and franchising since 2019, the brand has grown to over 300 locations with services expanding into peptide therapy and bioidentical hormone replacement.
At a Glance
- Minimum Liquid Capital Required: $150,000
- Ownership Model: Owner-operator or semi-absentee
- Location Type: Retail spa
- Time Commitment: Full-time or semi-absentee with manager
- Experience Required: None; medical staff handles clinical operations
Top 5 Reasons to Invest
- Entrepreneur’s #1 ranked IV Therapy franchise
- Recurring revenue through membership model
- 300+ locations validates proven system
- Semi-absentee ownership structure available
- Expanding services: peptides, NAD+, BHRT
Prime IV Hydration & Wellness Franchise
Prime IV was founded in 2017 by Amy Neary, a healthcare entrepreneur who had operated a lab testing company since 2008. She identified demand for accessible, preventive wellness solutions and launched Prime IV to deliver customized IV therapies with 100% nutrient absorption — something oral supplements cannot achieve.
The franchise launched in 2019 and grew through the pandemic as consumers prioritized immune health. Today, Prime IV operates over 300 locations across 42 states, earning Entrepreneur’s #1 IV Therapy ranking in both 2024 and 2025, plus recognition from Franchise Business Review as a Top Franchise for Women.
Why Franchise With Prime IV?
- Category leadership — Entrepreneur’s #1 IV Therapy franchise for two consecutive years validates brand strength and operational systems.
- Membership-driven revenue — Recurring subscriptions create predictable monthly income beyond one-time service visits.
- Expanding service menu — Peptide therapy, NAD+ infusions, and BHRT for men and women add revenue streams as clients’ needs evolve.
- Semi-absentee structure — Lean staffing model (2-3 licensed professionals) allows ownership with a manager in place.
- Turnkey launch system — Prime Academy training covers clinical protocols, operations, compliance, marketing, and staff management.
ABF Exclusive Insights
Market Analysis: The global IV therapy market is projected to reach $19.6 billion by 2027. Consumer demand for preventive wellness, immune support, and performance optimization continues accelerating post-pandemic, with IV therapy becoming a mainstream solution rather than a niche service.
Competitive Advantage: Prime IV combines proprietary formulations with a spa-like “1 Hour Vacation” experience that competitors struggle to replicate. The addition of peptide therapy and BHRT creates multiple revenue streams from the same client base — when needs evolve, clients stay.
ABF Timing Insight: With 300+ locations and consistent Entrepreneur #1 rankings, Prime IV has established category dominance. Franchise Business Review’s Culture 100 and Top Franchise for Women awards indicate strong franchisee satisfaction — a leading indicator of system health.
Training & Support
- Prime Academy onboarding — Multi-day in-person training covers operations, clinical protocols, compliance, customer experience, marketing, and hiring at a live operating spa.
- Real estate and buildout guidance — Corporate team assists with site selection, construction, and spa setup to maintain brand standards.
- Pre-opening launch support — Marketing and business development strategies activate before doors open to build initial client pipeline.
- Ongoing coaching — Regular performance reviews, coaching calls, and access to proprietary SOPs and operational playbooks.
- Continuous clinical education — Updates on emerging therapies, best practices, and compliance ensure franchisees stay current in a regulated industry.
Franchise Owners That Thrive
- Passionate about health, wellness, and preventive care
- Comfortable hiring and leading licensed clinical staff
- Interested in scaling to multiple locations over time
- Willing to follow a proven, turnkey system
- No medical background required
Franchise Fit & Capital Readiness
Who Is NOT A Good Fit for This Franchise
Are you seeking fully passive ownership with no involvement? Semi-absentee requires management oversight.
Are you uncomfortable in a regulated healthcare environment? Clinical compliance is non-negotiable.
Do you expect immediate profitability without ramp-up? Building a membership base takes time.
Do you have less than $100,000 to $150,000 in liquid capital?
If you answered yes to any of these, this franchise may not be the right fit. Candidates who do not meet the financial criteria below are typically not approved by the franchisor.
Investment Readiness Check
- Minimum Liquid Capital: $150,000 — required for consideration
- Ownership timeline: 6–12 months from signing to opening
- Credit and net worth verified during qualification
- Total investment ranges $187,701 – $631,194 depending on location
- Multi-unit development available for qualified candidates
All financial thresholds are set by the franchisor and are non-negotiable during approval.
Franchisor Authority Disclosure
America’s Best Franchises provides guidance and introductions. Final approval criteria, financial thresholds, and territory decisions are determined exclusively by the franchisor.
Frequently Asked Questions
Q. Do I need a medical background to own a Prime IV franchise?
A. No. Franchisees hire licensed medical professionals to handle clinical operations. Business acumen and leadership skills matter more than healthcare experience.
Q. Is semi-absentee ownership realistic?
A. Yes. The lean staffing model (2-3 licensed professionals) allows semi-absentee ownership with a qualified manager in place. Many franchisees operate this way.
Q. What services does Prime IV offer beyond IV therapy?
A. Prime IV has expanded into peptide therapy, NAD+ infusions, and bioidentical hormone replacement therapy (BHRT) for both men and women — creating multiple revenue streams per client.
Q. Is there a veteran discount?
A. Yes. Prime IV is a VetFran member and offers a 15% discount on the franchise fee for qualified veterans.
Next Steps
By submitting this form, you confirm that you meet the minimum liquid capital requirement of $100,000 established by the franchisor.
Complete the form below to request a qualification review and discuss territory availability for Prime IV Hydration & Wellness.
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This profile represents general franchise information. Individual results may vary. Refer to the Franchise Disclosure Document for complete details.